Basically it is a very good board. As a proud(?) owner I can share some of my experiences regarding this board.
There indeed are some uncertainities with this board. I also had some miscellaneous problems with the latest bios (2822) but they all disappeared with a tad older bios (2617). This is clearly a software issue and thus nothing to worry about.
Also some particular features of this board are a bit suspicious:
USB2 - Some say it works and some say it doesn't. This could be a driver issue. I refuse to believe that EPoX would have released a board with completely broken USB2 support.
HyperThreading - It's almost positive that this board will never support HT. Facts are that the board uses Stepping A 845G chipset (Intel says it doesn't work with HT) and EPoX itself states that the board doesn't support HT. This could be a crushing defeat for the 4G4A series.
Everything else (LAN, RAID, etc) seem to work perfectly. However, the lacking HT support is a major letdown and if it indeed turns out that the board will never support it, I wouldn't recommend it.