Not all chipsets/boards support ECC, or Registered ECC DIMMs. Make sure it does before buying. I'ave rtead in the case of some DDR boards if you fill all slots you need Registered RAM. Yes performance theoretically takes a minor hit, but when using programs such as StudioMax, Photoshop, and other data intensive work it's a real boon. Many high end workstation/servers use this type of memory.