I've had 2 power supplies give me great deviations from the +-5 and +-12 and I learned the hard way. First time, my motherboard fried but the CPU was still good. Second time, on another computer, the MB and CPU went with it. A great learning lesson.
I've also had cheap power suppies from Fry's Electronics. Bought a case from them, took it home, powered it up, and flames and smoke came out of the PS. Now that's a load of crap.