You lost me.. so you're getting rid of a drive, no big deal.
Where are you moving the contents of that drive TO?
If you're just asking if you can take an old system disc that is currently the boot drive/partition e.g. C: and replace that physical disc drive with a different one and move the data, operating system, programs, and all to a replacement drive and end up with a bootable OS on the new drive with all your programs / data, yes, just make a partition clone of the old drive/partition onto a new partition on the new drive, you're done.
Now if you're asking if it is possible to take the PROGRAM FILES et. al. (i.e. installed programs) on ONE drive and ADD/MERGE them to the ALREADY WORKING / INSTALLED programs on ANOTHER OS drive while KEEPING the OS and already installed stuff on the DESTINATION drive, uh, yeah, that is difficult and sometimes impossible and often leads to stuff that is at least somewhat messed up. There's nothing really wrong with just copying program directories out of the Program Files et. al. folders to another system and so on, but you generally don't end up with things installed in the "start menu" and the desktop shortcuts, you'll probably lose your user profile / preferences stuff since that is often in the registry or in your user Application Data et. al. folders, et. al.
For the first case, whole partition copy to a new drive, though --
You can use partition imaging / cloning tools to copy or backup and restore (possibly onto a totally different drive / partition) any given partition.
Paragon Drive Backup Express (requires name and email for registration)
http://www.paragon-software.com/home/db-express/
Macrium Reflect (props to Airjrdn for suggesting this)
Macrium
http://www.macrium.com/reflectfree.asp
If you have a Seagate or Maxtor hard drive, you can use the DiscWizard (Seagate) or MaxBlast (Maxtor) software.
http://www.seagate.com/www/en-us/support/downloads/
Look at bottom of page under "General Software"
Seagate and Maxtor
I haven't tried this one but it looks promising.
Self Image
http://selfimage.excelcia.org/
freeware as in open source:
http://www.clonezilla.org/
http://gparted.sourceforge.net/features.php
Commercial software some of which are limited capability versions that are freely given out in one version, and have more capabilities if you pay for a better version:
http://www.macrium.com/ReflectFree.asp
http://www.terabyteunlimited.com/index.htm
http://www.paragon-software.com/home/db-express/
http://www.macrium.com/ReflectFree.asp
http://www.fssdev.com/products/casper/
Maybe free commercial software with limited capabilities:
These are basically limited versions of Acronis' product AFAIK.
http://www.seagate.com/www/en-us/support/downloads/
"DiscWizard" is free *if* you have a Seagate drive connected to your system.
"MaxBlast" is free *if* you have a Maxtor drive connected to your system.
Popular commercial software on sale:
(actually this one below, acronis' true image home 11 is NOT free, but is $10 or so; the vnunet link is supposedly the current / best deal that still is offered -- the price depends on which links you click to buy it.. confusing, I know...)
http://acronis.com/homecomputing/products/trueimage/
http://www.acronis.net/promo/ati4free/
http://www.vnunet.com/vnunet/d...cronis-true-image-home