i found that when you have a really hot system because of overclocking and fast video cards (v5 or GTS) to just leave the case off. i have a rather large case (6 visible 5.25, 6 hidden 3.5, 2 visible 3.5) and when it was all closed up, you could have fried an egg on the outside of the case. to fix this problem, i just took the case off and attached a 3 foot house fan to the side of the tower and heat problems are a thing of the past. i dont think that would be either positive or negative pressure, there is nothing surrounding it to differeniate between the two.
i have also never had to clean my case...ever. i am not sure why this works so well...everything ive ever read said never have the case off. but, this works like 100% better, for me anyways. it looks like a big PITA but its really not. oh well, just my 2 cents for the day =)