sad .. but accurate. relatively recent finding, too, because obesity is pretty much a modern affliction, but also because we didn't have the science bits needed to find this out.
you CAN permanently lose fat cells. It takes several years of maintenance, you basically need to keep lean and wait for the cells to die, they won't be replaced by other empty fat cells.
I know this is a thread about the joy of stuffing yo' face, but i'd like to point out that our problem is not calorie consumption, it's the extreme reduction in physical strain that the majority of people experience. i recall reading a US Marine saying "a diet of 5000 calories a day (twice the food of an ACTIVE city human) will starve anyone in Boot Camp".
The point in my life where i was thinnest and healthiest i was not being conservative at all with food. Fried chicken, eat whenever you want, always go for Large, eat whatever you want, ice cream, but i was also sleeping 30 hours a week, going to college in the morning and to the afterhours at night, gigging, walking, partying, cube dancing even, adding calories with beer and removing them with extasy. I was ridiculously active and just couldn't keep the weight on.
Then i sat down in front of a work PC and .. game over man.