This all depends on what kind of motherboard you've got, or are looking at. Some things to know though:
There was SDR sDRAM, usually just called sDRAM (Single Data Rate Synchronous Dynamic Random Access Memory); it came in PC66, PC100, and PC133 - the numbers there indicate the MHz rating. There's no double rate here; the MHz rating there is what the RAM runs at.
Then came DDR - Double Data Rate. It is still sDRAM, but as pspada pointed out, it transfers data twice per clock cycle. It has a different number of pins, and uses a different socket than SDR RAM did. It comes in many varieties nowadays, the norms being PC1600, PC2100, PC2700, and PC3200. Those numbers come from the theoretical effective speeds of the RAM - PC1600 was supposed to have 1.6GB/sec of bandwidth, PC2100 2.1GB/sec, etc. PC1600 ran at 100MHz, but had an effective speed of 200, since it transferred twice per cycle. PC2100 - 133MHz, 266 effective. PC2700 - 166MHz, 333 effective. PC3200 - 200MHz, 400 effective.
So, when people talk about FSB400, that's actually 200MHz, but since it's DDR, it's effectively 400.
Hopefully that made some sense, and even cleared up things for you.