Originally posted by: SacrosanctFiend
Originally posted by: Riprorin
I'm O+ but I'm considered a "rare" donor apparently because I have very few antigens. Do you understand the nature of the interaction between blood antigens and antibodies?
I assume that being O+ combined with having few antigens makes me a good universal donor.
I understand antigens and antibodies quite well, as my Microbiology research paper was on autoimmunological diseases. You need to understand that a person with Rh- blood will
develop Rh antibodies if he/she recieves Rh+ blood (it takes time for the antibodies to develop, so while the first transfusion may not have any negative effects, it will happen with reoccuring transfusions), and the result is agglutination. Agglutination won't always happen, but it can be fatal if it does. We can get into the polygenetic inheritance of Rh, but it doesn't make a difference since + and - is determined only by the D-antigen.