If I get around to it I'm going to see if I can find a replacement I/O port for it. I just don't remember the name of the case to search for it. It might be a Rocketfish. Not sure though. It's been over 5-6yrs since i bought it - Fantastic case!
5 to 6 years old. . . . You didn't say whether this is USB2 or USB3, but I'm beginning to suspect the former.
I've had difficulties with either type, nevertheless exceptions to the rule.
A rear USB2 I/O-plate port on a 780i motherboard we just "decommissioned" had gone bad some years ago, while the remainder seemed to work fine. The windows pop-up message is always a nuisance at startup.
Another case was a SYBA USB3 3.5" front-panel hub I attempted to kloodge with the 20-pin Asmedia header. It seemed to be working for at least a year, but after that (with certain changes in overall motherboard hardware usage) would throw up an "insufficient resources" message.
It's possible that it's the case port hardware or the wiring -- at a margin of continued functionality. If USB2, I'd disconnect the case ports and install a 4-port USB2 hub connecting to a single 10-pin motherboard port. If USB3, the same for troubleshooting, and there are $17 two-port 3.5" front-panel molded ports-with-wire/mobo-plug -- "ConnectLand" is the one sold at Egg these days.
The other possibility is a USB2 PCI card. So very cheap! The ones I've used have a "type A" connector for internal cabling as well as some 4 or 5 USB ports at the PCI plate. With that type of solution, you could just turn off your motherboard USB2 feature entirely -- or so I'd think.
But -- test everything. You might even be able to repair it, or even replace the port hardware of the case. Ultimately, it's about "costs and benefits" in time -- not dollars. I wouldn't get my panties in a bunch about a single case-USB-port, though. Imperfections abound everywhere, as do solutions.