Just because the timing is right....
I've recently had a motherboard start giving me problems. Yesterday a Replacement board came in and I re-installed Vista64 (I went from a p35 Motherboard to an i780). I used my backups to recover my Data. It was very nice to not have to worry about forgetting some data somewhere or having to try and rescue the data off of a dying system.
My initial set up was to configure the new PC as a RAID5 system. Everything worked fine and I recovered all my Data and reinstalled all my apps, but there were some performance issues I just didn't like. So, I dropped the RAID5 array and went to RAID0. I used the "recovery CD" that came with my Windows Home Server and it worked extremely well. 30 minutes later I was back up on the RAID0 array with Windows and all my Applications intact.
So, yes, it works quite well on Vista64.
You know, when WHS was first announced I was definitely loving the whole concept. Unfortunately I just couldn't afford one at the time and the whole thing just dropped out of my thoughts. Late last year my finances finally got back to normal and I went out and picked up the HP WHS. It has since become a very important part of my network and I heavily use it on a daily basis. I really can't recommend it enough to folks.